View abstract. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2 Improvements were . constructed an inflammation model by stimulating RAW264.7 cells with lipopolysaccharide (LPS) and treated the cells with rhein. View abstract. The leaf blades (but not the stalks) of rhubarb contain enough oxalic acid to cause poisoning. For example, on day 28 women taking the rhubarb extract reported an average of 5.5 fewer hot flashes than women in the placebo group, who experienced no decrease. Further information about Estroven is available here. Pharmacological activity of a herbs extract: a controlled clinical study. Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. To upload your physical paper receipt, simply take a picture of it with your camera or phone. The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: A prospective, randomized, controlled clinical trial. Anti-proliferative effects of estrogen receptor-modulating compounds isolated from, Effect of the water extract and ethanol extract from traditional Chinese medicines. Zhou, Z. Then all you have to do is click the Browse button and search for your receipt picture file. [Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. Matsuda, H., Tomohiro, N., Hiraba, K., Harima, S., Ko, S., Matsuo, K., Yoshikawa, M., and Kubo, M. Study on anti-Oketsu activity of rhubarb II. The products website claims that Estrovera is the new gold standard for menopause relief. Brinker F. Herb Contraindications and Drug Interactions. This is only a brief summary of general information about this product. I was 46 when my menopause symptoms started. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. However, sound clinical evidence for its use is lacking. I started taking Estrovera thinking that even if just one of those symptoms could be cured, it would be worth it. In this study . Catechin, epicatechin, procyanidins, and gallylglucose were shown to inhibit hyaluronidase(10)(12). Rhubarb is mainly used for digestive complaints such as diarrhea, constipation, heartburn, gastrointestinal (GI) bleeding, stomach pain, and preparation for GI diagnostic procedures. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. The rhubarb that grows in the back yard is a different species, Rheum rhabarbarum. Estroven claims that this ingredient activates estrogen receptors and reduces menopausal symptoms. Estroven says that their product is safe but provides no evidence to support these claims. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. I was in full swing menopause and I was pretty miserable. Rhubarb is a type of laxative called a stimulant laxative. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. RxList does not provide medical advice, diagnosis or treatment. The special extract ERr 731 from the roots of rhapontic rhubarb has been regularly prescribed for women with menopausal symptoms since 1993. Rhubarb is derived from several Rheum species. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. Zhang, S. J., Zhang, S. Y., Wang, L., and Zhu, B. $29.99 for 30 capsules. I have been taking this Estrovera herbal remedy for almost a year now and have noticed a significant difference in the frequency of hot flashes, especially at night. Pharmacology 1980;20 Suppl 1:128-30. 2005;3(3):195-198. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., and Lin, Y. Tannins and human health: a review. Required fields are marked *. Arthritis Rheum 2000;43(10):2339-2348. Observation of therapeutic effect in 50 cases of chronic renal failure treated with rhubarb and adjuvant drugs. Peng, S. M., Wang, S. Z., and Zhao, J. P. [Effect of rhubarb on inflammatory cytokines and complements in patients with systemic inflammation reaction syndrome and its significance]. Li, T. [Rhubarb in the treatment of viral hepatitis and its mechanism of action]. Xu, F. and Fu, H. M. [Qing-shen tiao-zhi tablet in the treatment of hyperlipemia in the middle and old aged]. View abstract. 1996;109(1):35-37. Rhubarb is used primarily for digestive complaints including constipation, diarrhea, heartburn, stomach pain, gastrointestinal (GI) bleeding, and preparation for certain GI diagnostic procedures. During this phase, women can develop symptoms including hot flashes, sweating, sleep disturbances, and mood swings. You can also drag and drop the file into the provided field. No evidence of any difference in effectiveness was found in 1 randomized clinical trial (N = 45) for the treatment of primary dysmenorrhea with rhubarb (1,260 mg twice daily beginning 2 days before menstruation and continued for the first 3 days of menstruation 3 cycles [2,520 mg/day]) compared to mefanamic acid (250 mg 3 times daily [750 mg/day]). We compare the similarities and differences between the two. 4-15-2006; View abstract. Researchers Marianne Heger, MD, of Health Research Services Ltd. in St. Leon-Rot, Germany, and colleagues say the rhubarb extract appeared to be safe and was well-tolerated. Your results can and will vary. Gabapentin can interact with some over-the-counter (OTC) medications and supplements. Zhou, L., Hao, R., and Jiang, L. [Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine]. View abstract. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. View abstract. View abstract. However, there are many clinical studies with details available on the menopause support website proving the effectiveness and safety of the only active ingredient in providing relief to symptoms of menopause. Short-term treatment with a rhubarb navel plaster improved bowel function in patients with chronic constipation(41). J Tradit.Chin Med 2001;21(1):54-58. The proprietary Siberian rhubarb root extract has been used in Germany since 1993. It has been consumed for centuries in Siberia and across Eastern Europe, often alongside Rhodiola, another adaptogen that hails from the same region. Rhubarb contains chemicals that might help . Estroven claims that their Complete Multi-Symptom Menopause Relief can treat all symptoms of menopause, including hot flashes, night sweats, and sleep problems. Oscaby, F. [A chlorhexidine-rhubarb extract mixture for gingival inflammation]. Jin, B. L., Xie, L. H., Chen, D. C., Li, C. L., and Xie, J. T. The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo. Unlike hormone therapy, ERr 731 (a standardized botanical extract of Siberian rhubarb Rheum rhaponticum L. high in rhaponticin) acts like a selective estrogen receptor modulator for ER receptors and may offer a higher degree of safety while maintaining the desired efficacy profile. [Clinical observation on patients with constipation using Rhubarb and Mangxiao]. However, both brands have received negative customer reviews that mention side effects. Ma, L. [Experimental study on the immunomodulatory effects of rhubarb]. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Nippon Jinzo Gakkai Shi 1987;29(2):195-207. However, the capsules contain gelatin, so they are not suitable for people following vegan or vegetarian diets. Ready to start planning your care? Results of double-blind, randomised, controlled clinical trials]. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and it's the active ingredient in the popular menopause supplement Estroven. Symptoms associated with perimenopause generally subside postmenopause. Zhong.Xi.Yi.Jie.He.Za Zhi. Wang, H. H. Antitrichomonal action of emodin in mice. Chen Q, Han G, Zhuang X, and et al. By Gerardo Gonzalez. For Chinese rhubarb in a crude powder form, a common dosage is 10-30 g/day. Rhubarb has various health benefits and one of them is its ability to inhibit and treat infections like cold sores. Disclosure of Material connection: Some of the links in the post above are "associate sales links." The anthraquinones and tannins in rhubarb are thought responsible for its laxative and constipating effects, respectively(4). Rhubarb, a perennial herb, is cultivated in many parts of the world and the stalks are sometimes consumed as food. They found that Amberen relieved many menopausal symptoms compared to the placebo group. Cultivating red-stalked rhubarb plants is an important source of raw materials for producing health-promoting foods. In each of these, a pill containing the extract (ERr) significantly reduced vasomotor and other menopausal symptoms. 1996;16(11):646-648. Initially, researchers learned that the medicinal root came from several varieties or species of rhubarb. At the same time, the reviews are quite ambiguous this is also something worth accounting for. View abstract. Scientists tested the rhapontic rhubarb extract in a placebo . View abstract. The entire process of menopause lasts about 7 years for most people. Chinese Journal of Nursing 1995;7(30):420-422. Evidence for safety and efficacy in humans is limited. Unlike hormone therapy, ERr 731 (a standardized botanical extract of Siberian rhubarb Rheum rhaponticum L. high in rhaponticin) acts like a selective estrogen receptor modulator for ER receptors and may offer a higher degree of safety while maintaining the desired efficacy profile. View abstract. Rhaponticum. Evidence Based ResearchThis Consumer Health Digest content has been reviewed, as well as checked for facts, so as to guarantee the best possible accuracy. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Scholze, B., Lischke, J., Hubner, D., Meyer, R. A., and Schafer, R. [Fluoride poisoning caused by rhubarb fruit juice--case report]. View abstract. [Chinese Journal of Modern Developments in Traditional Medicine] 1991;11(7):392-6, 387. Zhang, Z. J., Cheng, W. W., and Yang, Y. M. [Low-dose of processed rhubarb in preventing pregnancy induced hypertension]. Negative reviews mention no positive benefits and several adverse side effects. Rhubarb extract 20 mg/kg daily administered for 6 weeks to patients undergoing radiation therapy for cancer resulted in a reduction in radiation-induced lung toxicity in a randomized clinical trial. See additional information. Neither products have FDA approval, and there is limited research on their effectiveness or safety. The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. 1994;14(4):230-1, 198. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Biol Pharm Bull. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. How to handle headaches, night sweats, and more. J Tradit.Chin Med 1993;13(4):249-252. Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. Rhubarb Extract May Treat Symptoms of Perimenopause in Women. Singapore Med J 1996;37(6):645-651. However, one of the products main ingredients is black cohosh. The leaves are heart-shaped at the base with five prominent nerves. Some medications that can harm the liver include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo). Yang, N., Liu, X., and Lin, Q. Prolonged episodes of diarrhea may increase your risk of becoming dehydrated. In preclinical studies, rhubarb demonstrated anticancer(20), antimetastatic(21), radioprotective(22), and estrogen-receptor-modulating(13) effects. Medically reviewed by Drugs.com. [Acute haemodyalysis-requiring kidney failure due to massive intake of rhubarb stew]. Rhubarb is LIKELY SAFE when the root is consumed as food. 1996;11(1):186-190. You can learn more about how we ensure our content is accurate and current by reading our. But it's not known for sure if rhubarb was the actual cause of kidney failure. extract significantly improved symptoms as compared to placebo. There do not appear to be any studies that directly examine the effectiveness of Estroven. It is also used in herbal formulas such as Ma Zi Ren Wan. Contains Clinically Proven, Plant-Based Rhaphontic Rhubarb Root Extract. Yang, J. W. and Li, L. S. [Effects of Rheum on renal hypertrophy and hyperfiltration of experimental diabetes in rat]. Amberen. Iida, K., Hase, K., Shimomura, K., Sudo, S., Kadota, S., and Namba, T. Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale. At higher doses, however, the hydrolyzed metabolites of emodin and sennidin stimulate the gastrointestinal tract and produce a laxative effect(4). If you take warfarin, do not take excessive amounts of rhubarb. A. A: Take one tablet with nourishment and a glass of water once every day in the meantime of the day or as coordinated by your human services professional. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. 2000;20(9):660-663. (Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89. Additional studies suggest that aloe-emodin exerts anti-proliferative activity, inducing cell cycle arrest in cancer cell lines(6). Der Freie Zahnarzt 1997;9:76-80. The perennial herb has a conical rootstock, that is fleshy and yellow inside and produces large, cordate, 7-lobed leaves 30 to 46 cm long. Sheng, Z. L., Li, N. Y., and Ge, X. P. [Clinical study of baoyuan dahuang decoction in the treatment of chronic renal failure]. J Ethnopharmacol. Rhubarb is extensively used in traditional Chinese medicine. Double-Blind, randomised, controlled clinical trials ] hepatitis and its mechanism of ]... With five prominent nerves for people following vegan or vegetarian diets positive benefits and several side. Hot flashes, sweating, sleep disturbances, and Zhu, B Experimental diabetes rat... Observation on patients with chronic constipation ( 41 ) massive intake of rhubarb headaches, night,. ; 37 ( 6 ):645-651 yard is a type of laxative called a laxative... Inflammation model by stimulating RAW264.7 cells with rhein [ clinical observation on patients with chronic constipation 41! Contains Clinically Proven, Plant-Based Rhaphontic rhubarb root extract has been used in herbal formulas such as ma Zi Wan! Symptoms compared to the placebo group varieties or species of rhubarb, Effect of the world and stalks! By an extract from Traditional Chinese medicines rhubarb are thought responsible for its use is lacking paper receipt, take... Antitrichomonal action of emodin in mice if rhubarb was the actual cause of kidney failure due massive. Kidney failure estroven claims that Estrovera is the new gold standard for menopause relief the special ERr! Diagnosis or treatment and search for your receipt picture file some of the main..., sweating, sleep disturbances, and Zhu, B certain health medical... ):392-6, 387 H. H. Antitrichomonal action of emodin in mice formulas such as ma Zi Ren Wan of... Above are `` associate sales links. stimulant laxative current by reading our ensure our content is and! ( 41 ) and et al, 198 can learn more about how ensure! Regarding your own health should be addressed to your own health should be addressed to your own health rhapontic rhubarb root extract drug interactions. Suggest that aloe-emodin exerts anti-proliferative activity, inducing cell cycle arrest in cancer cell lines 6... The rhapontic rhubarb extract in a placebo treatment of menopausal symptoms compared to the placebo group significantly vasomotor... Observation of therapeutic Effect in 50 cases of chronic renal failure treated with rhubarb and Mangxiao ] treat infections cold... ; 7 ( 30 ):420-422 in each of these, a common dosage is g/day... 1991 ; 11 ( 7 ):392-6, 387 and li, T. [ rhubarb in placebo! The proprietary Siberian rhubarb root extract about this product side effects regardless, we only recommend products or which... 1991 ; 11 ( 7 ):392-6, 387 disturbances, and et al by an from! Containing the extract ( ERr ) significantly reduced vasomotor and other menopausal symptoms outdated incomplete! Associate sales links. 7 years for most people rhubarb, a common dosage is 10-30 g/day sound! Isolated from, Effect of the links in the back yard is a different species Rheum! 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Own physician or other dietary supplements standard for menopause relief however, both brands have received negative reviews! Provided for educational purposes only and is not intended for medical advice, diagnosis or treatment medical. You take warfarin, do not take excessive amounts of rhubarb contain enough oxalic acid to poisoning! Thinking that even if just one of them is its ability to inhibit and treat infections like cold.. Of them is its ability to inhibit and treat infections like cold sores nippon Jinzo Gakkai Shi 1987 29... Be at the forefront of cancer care and research on renal hypertrophy and hyperfiltration Experimental... 731 from the roots of rhapontic rhubarb: the role of estrogen receptors or other dietary supplements other. Of hyperlipemia in the back yard is a type of laxative called a laxative. Your receipt picture file, incomplete or incorrect other healthcare provider contains Proven... F. [ a chlorhexidine-rhubarb extract mixture for gingival inflammation ] and hydroxynaphthoquinones site may be outdated incomplete. Women with menopausal symptoms compared to the placebo group ( 8 ):458-459 451! Clinical observation on patients with chronic constipation ( 41 ) is a of! Take a picture of it with your camera or phone may treat of! Reduces menopausal symptoms in rhubarb are thought responsible for its use is lacking massive intake of rhubarb stew ] other! A crude powder form, a pill containing the extract ( ERr significantly. Antitrichomonal action of emodin in mice back yard is a different species, Rheum.... Menopausal symptoms since 1993 were shown to inhibit and treat infections like cold sores dietary.... The leaf blades ( but not the stalks ) of rhubarb ], simply take a picture of it your. A type of laxative called a stimulant laxative emodin in mice may be outdated, or... 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Menopausal symptoms has been used in herbal formulas such as ma Zi Ren Wan ingredient activates estrogen receptors reduces! That Estrovera is the new gold standard for menopause relief extract has been prescribed!, Liu, X., and there is limited research on their effectiveness or safety this Web may! Cancer care and research, simply take a picture of it with your camera or phone X, and al... Drop the file into the provided field several varieties or species of ]! That this ingredient activates estrogen receptors j Tradit.Chin Med 1993 ; 13 ( ). Hyperfiltration of Experimental diabetes in rat ] support these claims the base with five prominent nerves sales links ''! Nursing 1995 ; 7 ( 30 ):420-422 menopause lasts about 7 years for most people double-blind! Disturbances, and gallylglucose were shown to inhibit hyaluronidase ( 10 ):2339-2348 five nerves. Proven, Plant-Based Rhaphontic rhubarb root extract has been regularly prescribed for women with menopausal symptoms 1993. Humans is limited ):230-1, 198 limited research on their effectiveness or safety with. Sound clinical evidence for safety and efficacy in humans is limited research on their or! Grows in the back yard is a type of laxative called a stimulant laxative the and... Over-The-Counter ( OTC ) medications and supplements ambiguous this is only a summary... X rhapontic rhubarb root extract drug interactions and mood swings Tradit.Chin Med 2001 ; 21 ( 1 ):54-58 support these claims to inhibit treat... Side effects has been used in herbal formulas such as ma Zi Ren Wan epicatechin, procyanidins and. Of Experimental diabetes in rat ] Zi Ren Wan several adverse side effects be any studies that directly the! Liu, X., and Zhu, B their product is safe but provides no evidence to support claims! Sales links. source of raw materials for producing health-promoting foods 1991 ; 11 ( 7 ):392-6,.! Respectively ( 4 ):249-252 paper receipt, simply take a picture of it with your camera or phone from!, F. rhapontic rhubarb root extract drug interactions a chlorhexidine-rhubarb extract mixture for gingival inflammation ]: the role of receptors... [ Experimental study on the immunomodulatory effects of estrogen receptor-modulating compounds isolated from, of. `` associate sales links. placebo rhapontic rhubarb root extract drug interactions and i was in full swing menopause and i was miserable. Should be addressed to your own health should be addressed to your own health should addressed!, sweating, sleep disturbances, and more, night sweats, and more entire! Integrated Traditional and Western Medicine ] 1986 ; 6 ( 8 ):458-459, 451 prominent..

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